Whole Lung Irradiation in Rhabdomyosarcoma With Lung Metastases: A Report From the Soft Tissue Sarcoma Committee of the Children’s Oncology Group

Luo LY, Xue W, Qumseya A, Vasquez JC, Venkatramani R, Wolden SL, Casey DL. Whole Lung Irradiation in Rhabdomyosarcoma With Lung Metastases: A Report From the Soft Tissue Sarcoma Committee of the Children’s Oncology Group. J Clin Oncol. 2024 Dec 20;42(36):4263-4270. doi: 10.1200/JCO.24.00928. Epub 2024 Sep 10. PMID: 39255438; PMCID: PMC11652240.

Rhabdomyosarcoma patients with metastatic disease have a poor prognosis despite therapy intensification. The aim of this study was to investigate the efficacy of whole lung irradiation (WLI) in patients with rhabdomyosarcoma and lung metastases. Rhabdomyosarcoma patients with lung metastases enrolled on four Children’s Oncology Group protocols (D9802, D9803, ARST08P1, ARST0431) were retrospectively reviewed. Event-free (EFS) and overall survival (OS) were compared between patients who received and did not receive WLI.