Gupta S, Teachey DT, Chen Z, Rabin KR, Dunsmore KP, Larsen EC, Maloney KW, Mattano LA Jr, Winter SS, Carroll AJ, Heerema NA, Borowitz MJ, Wood BL, Carroll WL, Raetz EA, Winick NJ, Loh ML, Hunger SP, Devidas M. Sex-based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children’s Oncology Group report. Cancer. 2022 May 1;128(9):1863-1870. doi: 10.1002/cncr.34150. Epub 2022 Feb 24. PubMed PMID: 35201611; PubMed Central PMCID: PMC9007837.
Study ID Citation
Abstract
Boys with acute lymphoblastic leukemia (ALL) have historically experienced inferior survival compared to girls. We determined whether sex-based disparities persist with contemporary therapy and whether patterns of treatment failure vary by sex. We included patients age 1–30.99 years enrolled on frontline COG trials between 2004–2014. Boys received an additional year of Maintenance therapy. We explored sex-based differences in the distribution of various prognosticators, event-free and overall survival (EFS, OS), and subcategories of relapse by site.