Prognostic value of chest x-ray- and CT-defined large mediastinal adenopathy in high-risk pediatric Hodgkin lymphoma: A report from the Children’s Oncology Group Study AHOD0831

Lo AC, Lee I, Pei Q, Wu Y, McCarten KM, Hoppe BS, Hodgson DC, Roberts K, Milgrom S, Kessel S, Cole PD, Kelly KM, Cho SY. Prognostic value of chest x-ray- and CT-defined large mediastinal adenopathy in high-risk pediatric Hodgkin lymphoma: A report from the Children’s Oncology Group Study AHOD0831. Pediatr Blood Cancer. 2023 Aug;70(8):e30452. doi: 10.1002/pbc.30452. Epub 2023 May 27. PubMed PMID: 37243975; PubMed Central PMCID: PMC10546608.

We compared the prognostic value of chest radiograph (CXR)- and computed tomography (CT)-derived definition of large mediastinal adenopathy (LMA) in pediatric Hodgkin lymphoma (HL). 143 patients treated for stage IIIB/IVB HL on COG AHOD0831 were included in this study. Six definitions of LMA were investigated: (i) mediastinal mass ratio on CXR (MRCXR) >1/3; (ii) mediastinal mass ratio on CT (MRCT) >1/3; (iii) mediastinal mass volume on CT (MVCT) >200mL (iv) normalized mediastinal mass volume (MVCT/thoracic diameter [TD]) >1mL/mm, (v) mediastinal mass diameter on CT (MDCT) >10cm; and (vi) normalized mediastinal mass diameter (MDCT/TD) >1/3.