Penberthy L. Enrollment in Children’s Oncology Group’s clinical trials: population-based linkage with the National Childhood Cancer Registry

Lupo PJ, Siegel DA, Schussler NC, Alonzo TA, Adams S, Angelaszek D, Basavappa S, Chambers TM, Coyle L, Durbin E, Goderre JL, Hayes T, Howe W, Hsu E, Lee R, Lewis DR, Mariotto AB, Pollock BH, Preda A, Roth ME, Stevens J, Terranova T, Vargas SL, Hawkins DS, Penberthy L. Enrollment in Children’s Oncology Group’s clinical trials: population-based linkage with the National Childhood Cancer Registry. J Natl Cancer Inst. 2025 Sep 1;117(9):1868-1874. doi: 10.1093/jnci/djaf134. PMID: 40515409; PMCID: PMC12415956.

Improvements in outcomes among children and adolescents diagnosed with cancer are attributable to many factors, including clinical trials such as those administered through the Children’s Oncology Group (COG) as well as population-based resources such as the National Childhood Cancer Registry (NCCR). The objective of this study was to link COG trial data with the NCCR to evaluate overall enrollment patterns. Data were received from the NCCR and COG that were linked using an array of variables, then compared to evaluate enrollment patterns in COG studies from 2007 to 2018. Multivariable logistic regression was used to identify characteristics associated with not being enrolled in a COG study.