Outcome analysis of stage I epithelial-predominant favorable-histology Wilms tumors: A report from Children’s Oncology Group study AREN03B2

Parsons LN, Mullen EA, Geller JI, Chi YY, Khanna G, Glick RD, Aldrink JH, Vallance KL, Kim Y, Fernandez CV, Dome JS, Perlman EJ. Outcome analysis of stage I epithelial-predominant favorable-histology Wilms tumors: A report from Children’s Oncology Group study AREN03B2. Cancer. 2020 Jun 15;126(12):2866-2871. doi: 10.1002/cncr.32855. Epub 2020 Apr 8. PubMed PMID: 32267967; PubMed Central PMCID: PMC7717680.

Stage 1 epithelial-predominant favorable histology Wilms tumors (EFHWT) have long been suspected to have an excellent outcome. This study investigates the clinical and pathologic features of patients with stage 1 EFHWT in order to better evaluate the potential for reduction of chemotherapy and its associated toxicity. All patients registered on the COG AREN03B2 study between 2006 and 2017 with stage 1 EFHWT were identified. EFHWT were defined as tumors with at least 66% epithelial differentiation, regardless of degree of differentiation. Clinical information was abstracted from COG records. Event free survival (EFS) and overall survival (OS) were calculated and compared between groups based on age and therapy.