Nonorbital, Nonparameningeal Head and Neck Rhabdomyosarcoma: A Report From the Children’s Oncology Group. Pediatr Blood Cancer

Aye JM, Xue W, Gao Z, Ladra M, Indelicato DJ, Sheyn A, Dasgupta R, Arnold MA, Shenoy A, Linardic CM, Venkatramani R. Nonorbital, Nonparameningeal Head and Neck Rhabdomyosarcoma: A Report From the Children’s Oncology Group. Pediatr Blood Cancer. 2025 Jun;72(6):e31673. doi: 10.1002/pbc.31673. Epub 2025 Mar 19. PMID: 40108481; PMCID: PMC12165632.

Rhabdomyosarcoma (RMS) is the most common pediatric head and neck soft-tissue sarcoma. Intergroup Rhabdomyosarcoma Study I-IV demonstrated that patients with alveolar RMS (ARMS), Group III disease, or clinically involved regional lymph nodes had a worse prognosis. The outcomes and prognostic features of patients with nonorbital, nonparameningeal head and neck (NONPHN) RMS treated in subsequent Children’s Oncology Group (COG) trials have not been reported.