Management of chronic myeloid leukemia in children and adolescents: Recommendations from the Children’s Oncology Group CML Working Group

Athale U, Hijiya N, Patterson BC, Bergsagel J, Andolina JR, Bittencourt H, Schultz KR, Burke MJ, Redell MS, Kolb EA, Johnston DL. Management of chronic myeloid leukemia in children and adolescents: Recommendations from the Children’s Oncology Group CML Working Group. Pediatr Blood Cancer. 2019 Sep;66(9):e27827. doi: 10.1002/pbc.27827. Epub 2019 Jun 10. PMID: 31330093; PMCID: PMC6944522.

Chronic myeloid leukemia (CML) accounts for 2–3% of leukemias in children under 15 and 9% in adolescents age 15–19. The diagnosis and management of CML in children, adolescents and young adults have several differences compared to that in adults. This review outlines the diagnosis and management of the underlying disease as well as challenges that can occur when dealing with CML in this patient population.