Management and outcomes of chest wall rhabdomyosarcoma: A report from the Children’s Oncology Group Soft Tissue Sarcoma Committee

Lautz TB, Xue W, Luo LY, Fair D, Qumseya A, Gao Z, Dasgupta R, Rodeberg D, Venkatramani R. Management and outcomes of chest wall rhabdomyosarcoma: A report from the Children’s Oncology Group Soft Tissue Sarcoma Committee. Pediatr Blood Cancer. 2023 Jul;70(7):e30357. doi: 10.1002/pbc.30357. Epub 2023 Apr 18. PubMed PMID: 37070563; PubMed Central PMCID: PMC10391743.

Rhabdomyosarcoma (RMS) of the chest wall presents unique management challenges and local control considerations. The benefit of complete excision is uncertain and must be weighed against potential surgical morbidity. Our aim was to assess factors, including local control modality, associated with clinical outcomes in children with chest wall RMS. Forty-four children with RMS of the chest wall from low-, intermediate- and high-risk Children’s Oncology Group studies were reviewed. Predictors of local failure-free survival (FFS), event-free survival (EFS) and overall survival (OS) were assessed, including clinical characteristics and staging, primary tumor anatomic locations and local control modalities. Survival was assessed by Kaplan-Meier analysis and the log-rank test.