Magnetic resonance and computed tomography imaging features of epithelioid sarcoma in children and young adults with pathological and clinical correlation: a report from Children’s Oncology Group study ARST0332

McCarville MB, Kao SC, Dao TV, Gaffney C, Coffin CM, Parham DM, Hayes-Jordan A, Spunt SL. Magnetic resonance and computed tomography imaging features of epithelioid sarcoma in children and young adults with pathological and clinical correlation: a report from Children’s Oncology Group study ARST0332. Pediatr Radiol. 2019 Jun;49(7):922-932. doi: 10.1007/s00247-019-04389-2. Epub 2019 Mar 30. PMID: 30929036; PMCID: PMC6576270.

Fifteen people (6 males; median age 16.1 years, range 6.5–24.8 years) with epithelioid sarcoma enrolled in ARST0332 had preoperative imaging (MRI, n=10; CT, n=5) that was reviewed by two radiologists who recorded numerous features including presence and percentage of tumor necrosis, presence of surrounding edema, and lymph node involvement. Discrepancies between reviewers were adjudicated by concurrent re-review. We correlated imaging findings with histological assessment of percentage tumor necrosis, proximal- vs. classic-type histology, lymph node involvement and recurrence.