Pomaville M, Kao PC, Perez-Atayde A, London WB, George RE. Histologic Response to Induction Chemotherapy in High-Risk Neuroblastoma. Cancer Med. 2025 Nov;14(22):e71332. doi: 10.1002/cam4.71332. PMID: 41294259; PMCID: PMC12648435.
Study ID Citation
Abstract
Tumor histology at diagnosis is used in conjunction with other prognostic features to risk stratify patients with neuroblastoma and to assign therapy regimens. In patients with high‐risk disease, adjustment of therapy is tailored to treatment response, largely based on disease imaging following induction chemotherapy and resection of the primary tumor. The goals of this study were to (i) quantify changes in histologic features in the primary tumor between diagnosis and resection, and (ii) assess the prognostic capability of such alterations.