Group-based trajectories of health-related quality of life among pediatric patients with high-risk Hodgkin lymphoma

Williams AM, Rodday AM, Renfro LA, Wu Y, Henderson TO, Keller FG, Punnett A, Hodgson D, Kelly KM, Castellino SM, Parsons SK. Group-based trajectories of health-related quality of life among pediatric patients with high-risk Hodgkin lymphoma. J Natl Cancer Inst. 2025 Oct 1;117(10):2112-2119. doi: 10.1093/jnci/djaf197. PMID: 40700618; PMCID: PMC12505141.

Health-related quality of life (HRQoL) was recently demonstrated to improve throughout therapy for high-risk pediatric HL, however average scores may not reflect individual differences. This study aimed to identify subgroups of patients with similar HRQoL trajectories from pre- to post-therapy. AHOD1331 trial participants aged 11–20 (n=268 mean (SD) age 15.6 (1.9), 48% male) completed the Child Health Ratings Inventories–Global scale (HRQoL) prior to treatment, after cycle 2, after cycle 5, and the end of treatment. Group-based trajectory models (GBTM) identified latent clusters of individuals with similar HRQoL patterns over time. Multivariable multinomial logistic regression estimated the association between a priori defined characteristics and membership in trajectory-based groups. Log-rank tests examined differences in post-T4 progression-free survival (PFS) by trajectory groups.