Factors Associated With Primary Site Local Therapy in Patients With Nonmetastatic Ewing Sarcoma Treated With Interval-Compressed Chemotherapy: A Report From the Children’s Oncology Group

Ahmed SK, Binitie O, Krailo M, Indelicato DJ, Callan AK, DelRocco N, Buxton A, Chuba P, Christ A, Randall RL, Nadel H, Pawel B, Reed DR, Gorlick RG, DuBois SG, Janeway KA, Leavey PJ, Mascarenhas L, Laack NNI. Factors Associated With Primary Site Local Therapy in Patients With Nonmetastatic Ewing Sarcoma Treated With Interval-Compressed Chemotherapy: A Report From the Children’s Oncology Group. Int J Radiat Oncol Biol Phys. 2025 Nov 22:S0360-3016(25)06476-4. doi: 10.1016/j.ijrobp.2025.11.010. Epub ahead of print. PMID: 41285272; PMCID: PMC13052378.

Local therapy (LT) is a critical component of curative treatment for Ewing sarcoma (ES). This analysis evaluated clinical and treatment variables associated with local failure (LF) risk for nonmetastatic patients with ES.