Enhancing Prediction of Cancer Therapy-Related Cardiomyopathy From Surveillance Echocardiograms: A Children’s Oncology Group Study

Leger KJ, Stratton KL, Sachdeva R, Armenian SH, Bhat AH, Boyle PM, Edwards LA, Meacham LR, Narasimhan S, Nathan PC, Sadak KT, Sharma S, Border WL, Leisenring WM, Chow EJ. Enhancing Prediction of Cancer Therapy-Related Cardiomyopathy From Surveillance Echocardiograms: A Children’s Oncology Group Study. JACC Adv. 2025 Dec;4(12 Pt 2):102363. doi: 10.1016/j.jacadv.2025.102363. Epub 2025 Nov 21. PMID: 41273917; PMCID: PMC12681922.

Early echocardiographic indicators of cardiac remodeling may enhance cardiomyopathy risk prediction in childhood cancer survivors (CCS). The objective of the study was to assess whether influential echocardiographic measures can be combined to develop a robust cardiomyopathy risk prediction model in CCS.