Do children and adolescents with completely resected alveolar rhabdomyosarcoma require adjuvant radiation? A report from the Children’s Oncology Group

Aye JM, Chi YY, Tian J, Rudzinski ER, Binitie OT, Dasgupta R, Wolden SL, Hawkins DS, Gupta AA. Do children and adolescents with completely resected alveolar rhabdomyosarcoma require adjuvant radiation? A report from the Children’s Oncology Group. Pediatr Blood Cancer. 2020 May;67(5):e28243. doi: 10.1002/pbc.28243. Epub 2020 Mar 2. PubMed PMID: 32124549; PubMed Central PMCID: PMC7325864.

The role of adjuvant radiotherapy (RT) remains unclear in patients with localized. completely resected {group I) alveolar rhabdomyosarcoma (ARMS). Patients with group I ARMS enrolled on any one of three prior Children’s Oncology Group (COG) clinical trials (D9602, D9803, or ARST0531) were analyzed. All patients received systemic chemotherapy and 36 Gy adjuvant RT (if given) to the primary site at week 12 or week 4 for D9602/D9803 and ARST0531, respectively.