Current Treatment Strategies and Supportive Care Practices in the Care of Children and Adolescents With Mature B-Cell Non-Hodgkin Lymphoma: A Survey of Children’s Oncology Group Institutions

Belsky JA, Smith CM, Alexander S. Current Treatment Strategies and Supportive Care Practices in the Care of Children and Adolescents With Mature B-Cell Non-Hodgkin Lymphoma: A Survey of Children’s Oncology Group Institutions. Pediatr Blood Cancer. 2025 Jun;72(6):e31687. doi: 10.1002/pbc.31687. Epub 2025 Mar 22. PMID: 40119576; PMCID: PMC12636054.

Treatment strategies of mature B‐cell non‐Hodgkin lymphoma (B‐NHL) have been investigated in cooperative group settings to balance toxicity and cure. A survey of institutions participating in the Children’s Oncology Group (COG) was completed to assess current practice patterns for treatment strategies, supportive care, imaging, and potential interest in areas to de‐escalate for lower risk patients. The survey results demonstrate heterogeneity in treatment regimens for lower risk patient populations but near uniformity in treatment regimens for higher risk patients. The supportive care provided and imaging utilized also varied amongst institutions that provide opportunities for further investigation into best practices.