Children and young adults with newly diagnosed rhabdomyosarcoma metastatic to bone treated on Children’s Oncology Group studies

Schloemer NJ, Xue W, Qumseya A, Luo LY, Hiniker SM, Lautz TB, Rhee DS, Arnold MA, Venkatramani R. Children and young adults with newly diagnosed rhabdomyosarcoma metastatic to bone treated on Children’s Oncology Group studies. Pediatr Blood Cancer. 2024 Oct;71(10):e31200. doi: 10.1002/pbc.31200. Epub 2024 Jul 17. PubMed PMID: 39016936; PubMed Central PMCID: PMC11370626.

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Despite bone metastases being present in 5% of patients at diagnosis, there are limited studies examining these outcomes. We sought to define the prognostic factors, clinical courses, and outcomes of children treated on Children’s Oncology Group (COG) clinical trials with RMS metastatic to bone at diagnosis. We performed a retrospective analysis of patients diagnosed with bone metastatic RMS enrolled on COG RMS clinical trials (D9802, D9803, ARST0431, or ARST08P1) between 1997 and 2013.