Rich BS, Dicken BJ, Billmire DF, Weil BR, Ross J, Fallahazad N, Krailo M, Shaikh F, Frazier AL, Hazard FK, Nuño MM. Characterizing Lymphovascular Invasion in Pediatric and Adolescent Malignant Ovarian Nongerminomatous Germ Cell Tumors: A Report from the Children’s Oncology Group. J Pediatr Surg. 2023 Dec;58(12):2399-2404. doi: 10.1016/j.jpedsurg.2023.08.008. Epub 2023 Aug 22. PubMed PMID: 37699777; PubMed Central PMCID: PMC10872999.
Study ID Citation
Abstract
Lymphovascular invasion (LVI) has been identified as a poor prognostic factor for a variety of tumors; however, its significance in malignant ovarian germ cell tumors (MOGCT) in pediatric and adolescent patients is not well described. We aim to clarify the significance of LVI in the subset of patients with nongerminomatous MOGCT. Records of patients 0–20 years of age with MOGCT enrolled on Children’s Oncology Group study AGCT0132 were reviewed. Patients with documented presence or absence of LVI in either institutional or central review pathology reports were included.