BRAF Exon 15 Mutations in the Evaluation of Well-Differentiated Epithelial Nephroblastic Neoplasms in Children

Goldstein JA, Renfro LA, Jennings LJ, Mullen EA, Geller J, Vallance K, Fernandez CV, Perlman EJ. BRAF Exon 15 Mutations in the Evaluation of Well-Differentiated Epithelial Nephroblastic Neoplasms in Children: A Report From the Children’s Oncology Group Study AREN03B2. Arch Pathol Lab Med. 2024 Oct 1;148(10):e362-e366. doi: 10.5858/arpa.2022-0528-OA. PMID: 38116848; PMCID: PMC11186972.

The distinction between well-differentiated epithelial favorable-histology Wilms tumor (EFHWT) and metanephric adenoma (MA) in children has historically been determined by the required absence of both a fibrous pseudocapsule and mitotic activity in MA. More recently these features have been allowed in adult MA. Mutations in exon 15 of the BRAF gene are reported in up to 88% of MAs but have not been reported in EFHWTs.