Bilateral Wilms tumor with anaplasia: A report from the Children’s Oncology Group Study AREN0534

Romao RLP, Aldrink JH, Renfro LA, Mullen EA, Murphy AJ, Brzezinski J, Malek MM, Benedetti DJ, Cost NG, Smith E, Dome JS, Davidoff AM, Treece A, Parsons LN, Fernandez CV, Tornwall B, Shamberger RC, Paulino A, Kalapurakal JA, Geller JI, Ehrlich PF. Bilateral Wilms tumor with anaplasia: A report from the Children’s Oncology Group Study AREN0534. Pediatr Blood Cancer. 2024 Jul;71(7):e30981. doi: 10.1002/pbc.30981. Epub 2024 Apr 18. PubMed PMID: 38637871; PubMed Central PMCID: PMC11116047.

The purpose of this study is to examine the outcomes in children with anaplastic bilateral Wilms tumor (BWT) from study AREN0534 in order to define potential prognostic factors and areas to target in future clinical trials. Demographic and clinical data from AREN0534 study patients with anaplasia (focal anaplasia (FA); or diffuse anaplasia (DA)) were compared. Event-free survival (EFS) and overall survival (OS) were reported using Kaplan-Meier estimation with 95% confidence bands, and differences in outcomes between FA and DA compared using log-rank tests. The impact of margin status was analyzed.