Anthracycline-induced cardiomyopathy in childhood cancer survivors is associated with gene signatures of mitochondrial dysfunction-a COG ALTE03N1 report

Trainor PJ, Singh P, Wang X, Sharafeldin N, Zhou L, Hageman L, Armenian SH, Ginsberg JP, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Landier W, Bhatia S. Anthracycline-induced cardiomyopathy in childhood cancer survivors is associated with gene signatures of mitochondrial dysfunction-a COG ALTE03N1 report. Cardiooncology. 2025 Oct 6;11(1):87. doi: 10.1186/s40959-025-00391-w. PMID: 41053798; PMCID: PMC12502420.

Anthracycline-induced cardiomyopathy is a leading cause of morbidity and mortality in survivors of childhood cancer. The mitochondrion is a key mediator of the cytotoxic effects of anthracycline treatment and mitochondrial dysfunction is a hallmark of cardiomyopathy and heart failure. We sought to evaluate whether mitochondrial processes differ between anthracycline-exposed childhood cancer survivors who developed cardiomyopathy versus those who did not.