Singh P, Crossman DK, Cheng C, Trainor PJ, Sharafeldin N, Wang X, Zhou L, Hageman L, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ginsberg JP, Landier W, Bhatia S. Alternative mRNA splicing in anthracycline-induced cardiomyopathy – a COG-ALTE03N1 report. Cardiooncology. 2025 May 17;11(1):47. doi: 10.1186/s40959-025-00345-2. PMID: 40382596; PMCID: PMC12084991.
Study ID Citation
Abstract
Anthracycline-induced cardiomyopathy is a well-established adverse consequence in childhood cancer survivors. Altered mRNA expression in the peripheral blood has been found at the level of genes and pathways among anthracycline-exposed childhood cancer survivors with and without cardiomyopathy. However, the role of aberrant alternative splicing in anthracycline-induced cardiomyopathy remains unexplored. The present study examined if transcript-specific events, due to alternative splicing occur in anthracycline-exposed childhood cancer survivors with and without cardiomyopathy.