Alexander S, Kairalla JA, Gupta S, Hibbitts E, Weisman H, Anghelescu D, Winick NJ, Krull KR, Salzer WL, Burke MJ, Gore L, Devidas M, Embry L, Raetz EA, Hunger SP, Loh ML, Hardy KK. Impact of Propofol Exposure on Neurocognitive Outcomes in Children With High-Risk B ALL: A Children’s Oncology Group Study. J Clin Oncol. 2024 Aug 1;42(22):2671-2679. doi: 10.1200/JCO.23.01989. Epub 2024 Apr 11. PubMed PMID: 38603641; PubMed Central PMCID: PMC11616431.
Study ID Citation
Abstract
Many children treated for acute lymphoblastic leukemia (ALL) develop long-term neurocognitive impairments. Increased risk of these impairments is associated with treatment and demographic factors. Exposure to anesthesia is an additional possible risk factor. This study evaluated the impact of cumulative exposure to anesthesia on neurocognitive outcomes among a multicenter cohort of children with ALL.