Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma (NHL) includes over 70 types of cancers affecting white blood cells, which are part of the immune system. These cancers develop when genetic changes and other factors disrupt normal cell growth and functioning, and can present as enlarged lymph nodes, inflammation, or, more rarely, abdominal masses or rashes.

Common pediatric forms include mature B-cell lymphoma, lymphoblastic lymphoma, and anaplastic large cell lymphoma, among others. “Non-Hodgkin” distinguishes these diseases from Hodgkin lymphoma, a separate and more defined subtype. Langerhans cell histiocytosis (LCH) can resemble NHL but arises from a different type of white blood cell.

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COG’s Work in Non-Hodgkin Lymphoma

COG’s Non-Hodgkin Lymphoma Committee includes subcommittees focused on specific disease types, as well as Biology and Pathology Committees that study the mechanisms underlying pediatric lymphoma and LCH. Together, these groups develop biology studies and clinical trials aimed at advancing safer and more effective therapies for patients. Through shared expertise and continued research, this work supports improved treatment approaches and outcomes across NHL and related diseases.

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NHL: Key Statistics

  • > 0 %

    Survival rate for pediatric NHL in the US and Europe has increased from <20% over the last 50 years.patients.

  • 0

    New cases of pediatric NHL in the US annually.

Recent Publications

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While many children with non-Hodgkin lymphoma can be cured, treatment is often intensive, and not every subtype responds the same—driving COG researchers to develop more precise, less toxic therapies for every child.

COG Member Institutions

COG’s 220+ member institutions study and treat children and adolescents with cancer across a global network. These sites support patients from diagnosis through treatment and beyond, connecting families to clinical trials and specialized care closer to home.

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News from COG

As the world’s largest pediatric cancer research network, COG drives breakthroughs in treatment and improves outcomes for children with cancer. Explore the latest news and stories from across our global community.

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The future for children with Non-Hodgkin lymphoma is shaped by today’s research.

Your support helps fuel discoveries that deepen understanding and move us closer to cures and more effective treatments.

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